Born in Dubrovna, Belarus, Zvi Zeitlin was raised and educated in Israel, where he attended the Hebrew University in Judaic Studies (1940–43). At age 11, he became the youngest scholarship student in the history of the Juilliard School. Receiving a diploma and postgraduate diploma from Juilliard, Zeitlin studied with Sascha Jacobsen, Louis Persinger, and Ivan Galamian.
He has made solo appearances with the New York, Los Angeles, and Israel Philharmonic Orchestras, the Boston, Chicago, San Francisco, and Vienna Symphonies, La Scala, Concertgebouw Amsterdam, BBC, Orchestre National de France and Orchestre de la Suisse Romande. Zvi Zeitlin has made frequent tours of Europe, Australia, New Zealand, and Central and South America.